Fig. 8
From: Lipid order and charge protect killer T cells from accidental death
Mechanism of cytotoxic lymphocyte protection from secreted perforin. Illustration of a cytotoxic lymphocyte forming an immune synapse (shown are the microtubule-organizing centre and cytotoxic granule polarization), with granzymes (black dots) entering the target cells through perforin pores (light blue) in the target cell plasma membrane. High lipid order domains (red) and exposed phosphatidylserine (green) at the immunological synapse protect the lymphocyte against the perforin it secretes.
