Fig. 1: Recurrence and co-association of U2AF1 S34F mutations.
From: Functional significance of U2AF1 S34F mutations in lung adenocarcinomas
a Recurrence of U2AF1 S34F mutations in multiple data sets including data summarized from cBioPortal, TRACERx, Stanford patients, and cancer cell lines including LUAD. b The approximate phylogeny tree of the two samples collected from a Stanford LUAD patient, illustrating U2AF1 S34F mutation and CD74-ROS1 fusion as truncal events. c Co-occurrence of SLC34A2-ROS1 fusions and U2AF1 S34F mutations in LUAD subset of cohort in a: A total of 2112 cases were analyzed, with highlighted cases of S34F mutations and ROS1 fusions shown in red. A Fisher’s exact test was performed to determine statistical significance.
