Fig. 4 | Nature Communications

Fig. 4

From: RNA secondary structure prediction using an ensemble of two-dimensional deep neural networks and transfer learning

Fig. 4

Comparison of SPOT-RNA prediction with the native structure of a Synthetic Construct, Glutamine II Riboswitch, and Hatchet Ribozyme. The secondary structure of a synthetic construct RNA (chain H in PDB ID 6dvk), the Glutamine II Riboswitch RNA (chain A in PDB ID 6qn3), and Synthetic Construct Hatchet Ribozyme (chain U in PDB ID 6jq6) represented by 2D diagram with canonical base pair (BP) in black color, noncanonical BP in green color, pseduoknot BP and lone pair in blue color, and wrongly predicted BP in magenta color: a predicted structure by SPOT-RNA (at top), with 97\(\%\) precision and 77\(\%\) sensitivity, as compared with the native structure (at bottom) for the Synthetic Construct RNA, b the predicted structure by SPOT-RNA (at top) with 100\(\%\) precision and 81\(\%\) sensitivity, as compared with the native structure (at bottom) for the Riboswitch, c the predicted structure by SPOT-RNA (at top) with 100\(\%\) precision and 59\(\%\) sensitivity, as compared with the native structure (at bottom) for the synthetic construct Hatchet ribozyme.

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