Fig. 5
From: Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease
PKD1-mutated monkeys with numerous cysts can survive. a Cyst formation detected by ultrasonography in live monkeys. Arrowheads indicate cyst formation. Scale bar, 10 mm. b Box plot of renal function of each monkey at 6 and 12 months after birth. “UN” indicates urea nitrogen, “Cre” indicates creatinine, “B2m” indicates beta2-microglobulin, “UA” indicates uric acid, and “Cys C” indicates cystatin C. Large red dots indicate mutated monkeys. Small purple dots indicate wild-type monkeys grown at Shiga University of Medical Science. Small blue dots indicate wild-type monkeys grown at Shin Nippon Biomedical Laboratories. The top and bottom edges of boxes indicate the first and third quartiles, respectively; the center lines indicate the medians; and the ends of whiskers indicate the maximum and minimum values, respectively. Red lines indicate the average. Source data are provided as a Source Data file. n = 55 animals.
