Fig. 5
From: In silico prediction of high-resolution Hi-C interaction matrices
Assessing significant interactions and TADs from HiC-Reg predictions. a Fold enrichment of four configurations of CTCF motifs in significant interactions identified using true and predicted counts. A fold enrichment \(> \)1 (red horizontal line) is considered as enriched. Fold enrichment in all five cell lines is shown. b Fold enrichment of interactions identified using ChIA-PET experiments in significant interactions from HiC-Reg’s predictions and true counts. A fold enrichment \(> \)1 (red horizontal line) is considered as enriched. c Distribution of TAD similarity identified from true and predicted counts for all chromosomes. Each point in the box plot corresponds to the average Jaccard coefficient for a chromosome. The horizontal middle line of each plot is the median. The bounds of the box are 0.25 quantile (\({Q}_{1}\)) and 0.75 quantile (\({Q}_{3}\)). The upper whisker is the minimum of the maximum value and \({Q}_{3}+1.5* IQR\), where \(IQR={Q}_{3}-{Q}_{1}\). The lower whisker is the maximum of the minimum value and \({Q}_{1}-1.5* IQR\). d TADs identified on true (left) and predicted (right) HiC count matrices for selected regions. Top: Gm12878 cell line, chr17:32–34 Mbp. Bottom: K562 cell line, chr17:2–4 Mbp). Source data are provided as a Source Data file.
