Fig. 4: Disease gene enrichment in ESAM.
From: Edematous severe acute malnutrition is characterized by hypomethylation of DNA
a Experimental Factor Ontologies (EFOs) from the GWAS catalog (Methods) with two or more genes represented among ESAM differentially methylated clusters (DMCs) are shown on the vertical axis and grouped according to their shared parent EFOs. The overlap between disease and gene is indicated by a shaded box. The color key associated with each box represents the number of genome-wide significant SNPs for each gene for the listed EFO. b Weighted enrichment values for gene ontologies enriched by study DMCs (SGOs; vertical axis) and phenotypes associated with kwashiorkor (KGOs; horizontal axis) in the Human Phenotype ontology (HPO). SGOs that are not found in the KGO list receive a value of 0 by default, and SGOs that are found in the KGO list and in the top quartile of both lists would have a value of 1. Ranking of SGOs is indicated in descending order by the number in front of the SGO term and was based on their aggregate weighted enrichment score.
