Fig. 6
From: A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice
UVRAGFS promotes spontaneous tumorigenesis in mice. a Kaplan–Meier plot of time to development of any malignancy in Dox-treated iUVRAGFS mice (n = 25) versus Dox-treated control mice (n = 25). Malignancy is determined by complete histologic survey of all major internal organs. ***P < 0.001 (Log-rank test). b Representative images of DLBCL in different organs that developed in Dox-treated iUVRAGFS mice. c Percentage of control (n = 16) and UVRAGFS-expressing (n = 12) mice with spontaneous tumors, including lymphoproliferative disease (LPD), lymphomas, and non-lymphoid malignancies. d H&E and IHC analysis of the most frequently observed neoplastic lesions from Dox-treated iUVRAGFS mice using the antibodies as indicated. Scale bars, 100 μm.
