Fig. 5: Metabolomics variation at aGvHD onset is not affected by age, gender, nor BMI. | Nature Communications

Fig. 5: Metabolomics variation at aGvHD onset is not affected by age, gender, nor BMI.

From: Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites

Fig. 5

Recipients with or without GvHD were compared after adjustment for age, gender, and body mass index (BMI) and re-analyzed to avoid any metabolite variation due to these parameters. The list of 57 metabolites significantly changing with acute GvHD onset in both cohorts is available in Supplementary Data 13. The main pathways involved at GvHD onset were used to build a network of compositional data where nodes represent metabolites and are linked if the ratio between corresponding metabolites was not significantly different between groups of patients. The same network was first colored according to the considered sub-pathway for cohorts 1 and 2 (a and c, respectively) and then according to microbial-derived metabolites (red nodes) (b and d, respectively).

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