Fig. 6: Identification of main pathways involved in aGVHD using multivariate analysis. | Nature Communications

Fig. 6: Identification of main pathways involved in aGVHD using multivariate analysis.

From: Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites

Fig. 6

Principal component analysis was able to discriminate recipient with (red) or without (green) GvHD in dimension 1 for cohort 1 (a) and 2 (b). Sparse partial least square discriminant analysis (sPLS-DA) was then used to identify metabolites that mostly contribute to the discrimination of patients with (orange) or without GvHD (blue) for cohort 1 (c) and 2 (d). Complete list of metabolites is available in Supplementary Data 14. These metabolites were then used to identify main pathways involved in acute GvHD using overrepresentation analysis for cohort 1 (e) and 2 (f).

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