Fig. 4
Susceptibility of ADKIN RNAi-mediated knockdown and TbAT1-KO cell lines to 9. a Sensitivity of the RNAi clones targeting adenosine kinase (ADKIN). b Sensitivity of AT1-KO T. b. brucei strain, compared to the BS221 cell line from which it was derived. Results are expressed as the mean IC50 (µM), and error bars represent SEM and are based on two independent experiments (n = 2), each with two biological replicates. + = tetracycline-induced clones; − = non-induced clones. All experiments were performed with two independently generated RNAi clones (a, b). *P < 0.05, ***p < 0.001, ****p < 0.0001, Kruskal–Wallis test with Dunn’s multiple comparison test. Source data are provided as a Source Data file.
