Fig. 6 | Nature Communications

Fig. 6

From: Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness

Fig. 6

Investigation of the intracellular metabolism of 9. a Intracellular (deoxy)nucleotide levels after exposure to analogue 9 (black bars), compared to non-treated control cells (white bars). b Enlargement of less abundant nucleotides from a. c Determination of kinetic parameters of 9 incubated with purified recombinant TbADKIN enzyme. The graphs represent the average of 3–4 independent experiments with the error bars indicating SE (n = 4 for a, b and n = 3 for c). Source data are provided as a Source Data file.

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