Table 3 Kinetic parameters nucleoside analogue for P1 and P2 transporters.
Compound | P1 transporter | P2 transporter | ||||
---|---|---|---|---|---|---|
Km or Ki | ΔG0 | δ(ΔG0) | Km or Ki | ΔG0 | δ(ΔG0) | |
Adenosine | 0.12 ± 0.02 | −39.4 | 0.53 ± 0.02 | −35.8 | ||
3 Cordycepin | 210 ± 48a | −21.0 | 18.4 | 0.18 ± 0.02b | −38.5 | −2.7 |
8 7-Br-TUB | 4.85 ± 0.83 | −30.3 | 9.1 | 1.99 ± 0.31 | −32.5 | 3.3 |
9 3′-Deoxy-TUB | 99.9 ± 21.7 | −22.8 | 16.6 | 0.149 ± 0.03 | −38.9 | −3.1 |
10 7-Br-3′-deoxy-TUB | 9.47 ± 1.4 | −28.7 | 10.7 | 0.502 ± 0.14 | −35.9 | −0.1 |