Fig. 7
From: ProTargetMiner as a proteome signature library of anticancer molecules for functional discovery
The ProTargetMiner R Shiny package for deconvolution of drug target and MOA. a the ProTargetMiner R Shiny package interface. The input is the proteomics data for a desired compound and the output is the .CSV file containing the ranking of proteins for the compound against the desired panel in a PLS-DA model. Clicking on the interactive PLS-DA plot gives the attributes of the selected proteins, e.g. name, number of peptides, sequence coverage and significance compared to control, and will show the regulation of that protein in the compound panel. b step-by-step procedure of the use of ProTargetMiner R Shiny package. c the input .CSV template with the required columns.
