Fig. 7: PBRM1 loss and p21 loss positively correlate in human ccRCC tumors.
From: PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth
a 160 ccRCC tumors (40 tumors per stage) were used to generate a tissue microarray (TMA). Four foci from different regions of each tumor were selected. PBRM1 expression was analyzed and scored in our previous report47,48 (a, bottom). p21 expression was analyzed and scored in the tumors (a, top) by a blinded pathologist. Scale bar: 100 μm. b p-values of correlations between PBRM1 loss and p21 loss in human ccRCC samples. c A model depicting how PBRM1 may regulate tumor growth in ccRCC through recognition of p53 K382Ac. Source data are provided as a Source Data file.
