Fig. 1: Chemical-genetic profiling of AMPs.
a Schematic representation of the chemical-genetic pipeline. The chemical-genetic interactions of ~4400 single gene-overexpressions and 15 different AMPs were measured using a pooled fitness assay with a deep sequencing readout (see Methods). b A density scatter plot showing the overall correlation of replicate measurements of the chemical-genetic scores (log2 fold-change in the relative abundance of each gene in the presence vs absence of each AMP) across all genes and AMPs (r = 0.63 and P = 2.2 × 10–16, Pearson’s correlation, n = 53,292). c Heatmap showing the chemical-genetic interaction scores. Resistance-enhancing and sensitivity-enhancing chemical-genetic scores are represented by blue and red, respectively. Groups C1–C4 refer to clusters defined in Fig. 2. Source data are provided as Supplementary Data 2.
