Fig. 4: Collateral sensitivity (CS) interactions are frequent between AMPs with different modes of action. | Nature Communications

Fig. 4: Collateral sensitivity (CS) interactions are frequent between AMPs with different modes of action.

From: Chemical-genetic profiling reveals limited cross-resistance between antimicrobial peptides with different modes of action

Fig. 4

a Heatmap depicting the overrepresentation of collateral sensitivity-enhancing genes for each AMP pair over random expectation (n = 210 AMP pairs). Random expectation is calculated using the number of resistance-enhancing genes and sensitivity-enhancing genes for each AMP (see Methods). b Collateral sensitivity effects were especially pronounced between AMP pairs with different broad mode of action, that is, between membrane-targeting (C1, C2) and intracellular-targeting (C3, C4), as compared to AMP pairs from the same cluster. Significant difference: ***P = 1.7 × 10−08 from two-tailed unpaired t-test, n = 108 and 46 for pairs of AMPs between C1, C2, and C3, C4, and those within cluster, respectively. Y-axis shows odds ratio (log2) of enrichment of collateral sensitivity interactions between AMP pairs. Boxplots show the median (center horizontal line), the first and third quartiles (bottom and top of box, respectively), with whiskers showing either the maximum (minimum) value or 1.5 times the interquartile range of the data. Source data are provided as a Source Data file.

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