Fig. 7: Treatment responses in anaplastic versus favorable-histology WTPDX.

The Children’s Oncology Group (COG) EE-4A regimen is modeled by the vincristine and actinomycin-D 2-drug combination treatment, and the COG DD-4A regimen is modeled by the vincristine, actinomycin-D, and doxorubicin 3-drug combination treatment. RTV—median relative tumor volume (cm3).