Fig. 3: Paclitaxel-treated cancer cells activate type I IFN and TNFα through the cGAS/STING pathway. | Nature Communications

Fig. 3: Paclitaxel-treated cancer cells activate type I IFN and TNFα through the cGAS/STING pathway.

From: STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment

Fig. 3

a IFNB1 qPCR analysis in PDX treated or not by paclitaxel. b Global transcriptomic analysis in paclitaxel-treated PDX compared to untreated PDX using Enrichr omic tool LINCS L1000 Ligand Perturbations up. c TNF qPCR analysis in paclitaxel-treated or untreated PDX. n = 3 mice per group, Error bars indicate mean +/− SEM; Two-sided paired t-test. The symbols correspond to a p-value inferior to *0.05.

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