Fig. 3: Spatial learning-induced increase in VS spine density is vSUB-dependent. | Nature Communications

Fig. 3: Spatial learning-induced increase in VS spine density is vSUB-dependent.

From: Offline ventral subiculum-ventral striatum serial communication is required for spatial memory consolidation

Fig. 3

a Schematic representation of the experimental design. Scale bar: 50 µm. b Representative microphotographs of dendritic segments of a MSN in the VS for each experimental condition. Mean dendritic spine density/micrometer for cue and spatial trained mice was normalized to naïve mice (n = 6). Spatial training significantly increased spine density in the VS ipsilateral to the vehicle-injected vSUB (n = 7) as compared to cMWM (n = 5) trained mice. No change was observed in the AP-5 administered hemisphere (n = 5) (two-way ANOVA of training F1,18 = 18.162, p = 0.0005; treatment F1,18 = 8.056, p = 0.0109; training × treatment F1,18 = 5.329, p = 0.0331). Scale bar: 5 µm. Histograms represent mean ± SEM; *p < 0.05 spatial vs cue (Tukey).

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