Fig. 2: Substrate scope of alkynes. | Nature Communications

Fig. 2: Substrate scope of alkynes.

From: Copper-catalyzed enantioselective Sonogashira-type oxidative cross-coupling of unactivated C(sp3)−H bonds with alkynes

Fig. 2

Standard conditions: 1aa (0.2 mmol), alkyne (0.4 mmol), CuI (10 mol%), L5 (10 mol%), and Cs2CO3 (1.0 equiv.) in THF (2.4 mL) at rt for 16 h. Isolated yield based on 1aa is given. Ee values are based on HPLC analysis. aCuTc (15 mol%), L5 (10 mol%), and Cs2CO3 (2.0 equiv.) in THF at rt for 24 h. Bpin pinacolborato, TMS trimethylsilyl.

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