Fig. 4: Straightforward transformation. | Nature Communications

Fig. 4: Straightforward transformation.

From: Copper-catalyzed enantioselective Sonogashira-type oxidative cross-coupling of unactivated C(sp3)−H bonds with alkynes

Fig. 4

a The directing amide group was readily removed by sequential amide reduction to aldehyde and decarbonylation. b The essential alkyne moiety in the product was straightforwardly transformed into Z-alkene and alkane featuring chiral C(sp3)–C(sp2) and C(sp3)–C(sp3) bonds. c Silyl alkyne was easily converted to terminal alkyne, thus providing valuable chiral building blocks.

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