Fig. 5: Mechanistic investigations. | Nature Communications

Fig. 5: Mechanistic investigations.

From: Copper-catalyzed enantioselective Sonogashira-type oxidative cross-coupling of unactivated C(sp3)−H bonds with alkynes

Fig. 5

a The radical-clock substrate (±)-9 underwent ring opening before the C–C bond formation, thus indicating the initial generation of a benzylic radical. b The reaction of 1aa with copper acetylide did not occur in the absence of L5, indicating that both chiral ligand and terminal alkyne are indispensable for reaction initiation. c The reaction was proposed to proceed through sequential single-electron reduction of substrate 1, 1,5(6)-HAA, and copper-catalyzed C(sp3)–C(sp) coupling.

Back to article page