Fig. 5: Atoms in globomycin and myxovirescin with common positions in the complex structures. | Nature Communications

Fig. 5: Atoms in globomycin and myxovirescin with common positions in the complex structures.

From: Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin

Fig. 5

These are referred to in the text as ‘spine atoms’. a Superpose of the atoms in globomycin (yellow carbons, black labels) and myxovirescin (cyan carbons, blue labels) from crystal structures of the corresponding LspMrs complexes. Blocking hydroxyls are at the top of the image; the two oxygens are 0.8 Å apart. Nineteen atoms along the spine of the two antibiotics are within 1.3 Å of one another. (a.i). Chemical structure of myxovirescin. (a.ii). Chemical structure of globomycin. Overlapping atoms in the corresponding structures are shaded. b Alignment of the sequence of atoms and chemical groups in globomycin and myxovirescin that overlap in the structures of the corresponding LspMrs complexes. To the left and right, respectively, are shown parts of the consensus lipobox sequence (-LAGC-) in a prolipoprotein substrate and a non-cleavable tetrahedral intermediate analog isostere found in human immunodeficiency virus (HIV) protease inhibitor drugs as they might appear in complex with LspA14.

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