Fig. 1: Employing a gene’s cis-eQTL complement to identify genetic interactions. | Nature Communications

Fig. 1: Employing a gene’s cis-eQTL complement to identify genetic interactions.

From: Using regulatory variants to detect gene–gene interactions identifies networks of genes linked to cell immortalisation

Fig. 1

a SNPs within 1 Mb of a gene’s transcription start and termination sites were used to train an expression level prediction model using PredictDB. Predictions from these models correspond to the additive effect of all cis-regulatory variants for a given gene. b The observed expression of geneA can then be modelled as an interaction (X) between its cis-eQTL (predicted expression) and the observed expression of other genes in the genome (geneB). The error term represents, for example, uncaptured environmental or trans effects linked to variation in the expression of geneA, not capture by these other terms.

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