Fig. 2: Model prediction performance and validation. | Nature Communications

Fig. 2: Model prediction performance and validation.

From: Using regulatory variants to detect gene–gene interactions identifies networks of genes linked to cell immortalisation

Fig. 2

a R2 of predicted versus observed gene expression levels in the Lothian Birth Cohort (LBC1936) against the rank of the R2 value. Only the 5033 genes that passed the kurtosis threshold are shown. The horizontal line indicates an R2 = 0.1, for which the 1205 genes exceeding this threshold were retained for further analysis. b Validation of the LBC1936 gene prediction models using the 1000 Genomes data. Genes with an R2 > 0.1 across both datasets are plotted, with genes with an R2 > 0.5 in both datasets labelled. Genes annotated twice have more than one probe on the array used in the LBC1936 dataset.

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