Fig. 7: The proportion of variance explained by additive and interaction effects between cis-regulatory variants and the expression of distal genes. | Nature Communications

Fig. 7: The proportion of variance explained by additive and interaction effects between cis-regulatory variants and the expression of distal genes.

From: Using regulatory variants to detect gene–gene interactions identifies networks of genes linked to cell immortalisation

Fig. 7

A given interaction explains on average a an additional 0.68% of the variation in the gene’s expression in the Lothian Birth Cohort, and b an additional 2.0% in the GEUVADIS dataset. c The total set of non-redundant interacting genes identified by stepwise regression explained 13.2% of the variation in gene expression in the Lothian Birth Cohort and 17.6% in the GEUVADIS dataset, with the interaction effects alone explaining 2 and 5% of the variation on average respectively (points are coloured by gene name).

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