Fig. 1: Study design. | Nature Communications

Fig. 1: Study design.

From: Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke

Fig. 1

a Individual GRSs were derived in the UK Biobank training set (n = 11,995) using GWAS summary statistics for individual traits. b The metaGRS for ischaemic stroke was then derived by integrating individual GRSs using elastic-net cross-validation. c Validation of the metaGRS for ischaemic stroke was performed in the UK Biobank validation set (n = 395,393). UKB UK Biobank, GWAS genome-wide association study, GRS genomic risk score.

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