Fig. 4: The metaGRS for ischaemic stroke has comparable or higher predictive power than established risk factors.

Shown are the C-indices for incident stroke in the UKB validation set comparing the metaGRS with established risk factors. The reference model included the genotyping chip and 10 genetic PCs. Results are for the UKB validation set, excluding prevalent stroke events (n = 390,849). Red circles represent genetic/genomic scores; black circles represent non-genetic scores. Error bars represent 95% confidence intervals.