Fig. 5: Predicted cumulative incidence of ischaemic stroke.

Shown is the predicted cumulative incidence of IS in subjects with either (a) high levels of the metaGRS along with different risk factor levels (red: outside the guidelines; cyan: within the guidelines); or (b) risk factors within accepted guidelines along with different levels of the metaGRS (cyan: top 1% of the metaGRS; grey: middle 50% of the metaGRS; dark blue: bottom 1% of the metaGRS). Results are based on the UKB validation set, excluding prevalent stroke events (n = 390,849). Error bars represent 95% confidence intervals.