Fig. 2: HSC and MPP upregulate myelopoiesis associated genes in SpA. | Nature Communications

Fig. 2: HSC and MPP upregulate myelopoiesis associated genes in SpA.

From: GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis

Fig. 2

a–c In three separate experiments, mice (n = 8 per group) were injected with curdlan (arthritic) or PBS (healthy) before culling after 5 weeks and LT-HSCs, ST-HSCs, MPPs, and GMPs were isolated by FACS for RNA sequencing. a Scatter plot comparing genes differentially expressed between GMPs and MPPs in healthy animals (x-axis) with those differentially expressed in MPPs between healthy and spondyloarthritic animals (y-axis). b, c Heat map showing expression of selected genes upregulated in MPPs (b) and LT-HSCs (c) with development of SpA. Each column represents independent groups of eight pooled mice.

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