Table 4 Genes non-responsive to exercise in metabolically impaired individuals.

From: Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity

 

Aerobic training healthy, logFC

Aerobic training healthy, FDR

Aerobic training obese/T2D, logFC

Aerobic training obese/T2D, FDR

Resistance training healthy, logFC

Resistance training healthy, FDR

Resistance training obese/T2D, logFC

Resistance training obese/T2D, FDR

GUCY1B1

0.26

7.8E − 03a

0.09

9.7E − 01

0.11

2.0E − 01

0.02

1.0E + 00

KANSL3

 − 0.09

7.8E − 03a

 − 0.04

1.0E + 00

0.03

6.9E − 01

0.01

1.0E + 00

ARNT

 − 0.10

7.8E − 03a

 − 0.02

1.0E + 00

0.01

9.3E − 01

 − 0.05

1.0E + 00

TOP2B

 − 0.20

7.1E − 03a

 − 0.04

1.0E + 00

 − 0.09

5.5E − 02

0.00

1.0E + 00

IGIP

 − 0.19

7.1E − 03a

 − 0.03

1.0E + 00

 − 0.10

1.6E − 01

 − 0.03

1.0E + 00

COL6A6

0.24

7.9E − 02

0.04

8.1E − 01

0.36

6.2E − 04a

 − 0.03

1.0E + 00

APLNR

0.22

3.9E − 01

0.18

7.8E − 01

0.36

6.5E − 03a

 − 0.01

1.0E + 00

COL4A2

0.53

2.8E − 01

0.33

1.3E − 01

0.53

9.7E − 04a

0.19

1.0E + 00

PTGDS

0.09

8.2E − 01

0.07

1.0E + 00

0.37

5.7E − 04a

0.03

1.0E + 00

ABCG1

 − 0.07

8.2E − 01

 − 0.03

1.0E + 00

0.29

2.5E − 03a

 − 0.02

1.0E + 00

  1. Table presents the log(fold-change) before-after intervention and the false discovery rate (FDR). Genes considered specific for healthy individuals had FDR < 0.01 in healthy and FDR > 0.9 in metabolically impaired individuals (Obese/T2D). The top 5 up- and downregulated for aerobic and resistance were selected based on fold-change
  2. aSignificance at FDR < 0.05