Fig. 4: Integration site analysis suggests multiple clones contribute to CAR-T cell pools. | Nature Communications

Fig. 4: Integration site analysis suggests multiple clones contribute to CAR-T cell pools.

From: Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy

Fig. 4

a Bar chart depicts the percentage of integration sites found within an exon, intron, or not in a gene for CD8+ CAR-T cells. b Graphs represent the contribution (% frequency) of all identified clones by integration site analysis in IP and blood samples collected after infusion (x axis). Each color ribbon represents a unique clone demonstrating ≥1% frequency of sequence reads in a given sample. All other clones are grouped into the gray ribbon at the top of each graph. The total number of unique clones identified in the sample is listed underneath the sample ID for each graph (below the x axis).

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