Fig. 4: SVs associated with PD1/PDL1 genes and their increased expression. | Nature Communications

Fig. 4: SVs associated with PD1/PDL1 genes and their increased expression.

From: High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations

Fig. 4

a Patterns of SV, gene amplification (5 or more copies), RNF38->PDCD1LG2 gene fusion, and differential expression for CD274 (PD1 gene) and PDCD1LG2 (PDL1 gene), for the subset of cases with associated SV or amplification for either gene. Differential gene expression patterns relative to the median across sample profiles. b Gene expression levels of CD274 and of PDCD1LG2, corresponding to the position of SV breakpoints located in the surrounding genomic region on chromosome 9 (representing 66 SV breakpoints involving 19 cases). Median expression for unaltered cases represents cases without SV or amplification. See also Supplementary Data 4.

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