Fig. 5: Model of inhibition of 5FC/5FU toxicity by uxs1 mutation. | Nature Communications

Fig. 5: Model of inhibition of 5FC/5FU toxicity by uxs1 mutation.

From: 5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus

Fig. 5

Potential mechanisms by which uxs1 mutations may confer resistance to both 5FC and 5FU. Mutation of uxs1 causes an accumulation of UDP-glucuronic acid, the product of Ugd1, which either impairs production of toxic fluoridated molecules or rescues inhibition of the targets of those fluoridated molecules, such as thymidylate synthase. Protein names are in red for those where mutations were found in this study.

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