Fig. 5: MKK6-p38α MAPK signaling mediates villus premature aging caused by Tsc1 deficiency.
From: Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway
a–c Mapk14 haplodeficiency rescued the deterioration in villus structures (a), decreased nutrient absorption activities (b), and compromised regeneration (c) at 8 month of age. Data are expressed as mean ± SEM. N = 5 mice per group. *P < 0.05, **P < 0.01 (determined using Student’s t test). d Mapk14 haplodeficiency rescued the decreases in the numbers of ISCs and proliferating ISCs in 8-month-old Lgr5-GFP-CreERT;Tsc1f/f mice. The intestinal sections were immunostained for PCNA, and cells positive for PCNA and GFP were counted and normalized to the number of Lgr5+ ISCs. Bottom panels: quantitation data (mean ± SEM). N = 5 mice per group. *P < 0.05, **P < 0.01 (determined using Student’s t test).
