Table 1 Summary of binding affinities measured by ITC between various fragments of liprin-αs and LAR-RPTPs.

From: Structural basis of liprin-α-promoted LAR-RPTP clustering for modulation of phosphatase activity

Liprin-α

LAR-RPTP

Kd (μM)

α2_SAM123

LAR_D1D2

3.4 ± 0.1

α2_SAM1

LAR_D1D2

Not detectable

α2_SAM23

LAR_D1D2

Not detectable

α2_SAM123

LAR_D2

14 ± 1

α2_SAM123∆N

LAR_D1D2

12 ± 1

α2_SAM123∆Insertion

LAR_D1D2

3.0 ± 0.4

α2_SAM123∆Insertion

PTPR-σ_D1D2

2.4 ± 0.3

α2_SAM123∆Insertion

PTPR-δ_D1D2

6.4 ± 1.5

α1_SAM123

LAR_D1D2

3.8 ± 0.8

α3_SAM123

LAR_D1D2

3.6 ± 0.2

α4_SAM123

LAR_D1D2

5.9 ± 0.6

  1. The corresponding titration curves can be found in Fig. 1c, Fig. 2i, and Supplementary Fig. 3
Back to article page