Fig. 5: Motif signatures at sites loosing accessibility. | Nature Communications

Fig. 5: Motif signatures at sites loosing accessibility.

From: Mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1

Fig. 5

a De novo-derived motifs enriched across regions that lost accessibility upon PU.1 induction in CTV-1 cells. The best motifs corresponding to known factor families derived from individual clusters are shown. The significance of motif enrichment (hypergeometric test) and the fraction of motifs in peaks (background values are in parenthesis) are given for the top five motifs corresponding to known motif families. b–d Representative ATAC-seq footprints across enriched motif-centered peaks that either lost or gained accessibility upon PU.1 induction in CTV-1 cells. Footprints of control cells (mutPU.1) are in grey, footprints of PU.1 mRNA-transfected cells are colored. Smaller histograms in the upper right corner zoom into the central part of the main graph. The position of the PU.1 motif is indicated by two vertical dashed lines. a–d Source data are provided as a Source Data file.

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