Fig. 3: Pharmacokinetics of bNAb treatments. | Nature Communications

Fig. 3: Pharmacokinetics of bNAb treatments.

From: Single-dose bNAb cocktail or abbreviated ART post-exposure regimens achieve tight SHIV control without adaptive immunity

Fig. 3

a, b Plasma concentrations of PGT121 and VRC07-523 in Group 2B animals (5 mg/kg each bNAb at 48 h and on days 4, 7, and 10). Except for 36494, no animal had detectable PGT121 or VRC07-523 in plasma after week 6. c, d Endogenous anti-drug antibody (ADA) responses against passively administered bNAbs for Group 2B animals. e, f Plasma concentrations of PGT121 and VRC07-523LS in Group 3 animals (20 mg/kg each bNAb at 30 h). g, h Endogenous ADA responses against passively administered bNAbs for Group 3 animals. Concentrations of each bNAb were measured by ELISA using binding to ST0A9 (PGT121) or RSC3 (VRC07-523 and VRC07-523LS). Dotted lines indicate limits of detection. Group colors and individual animal symbols are consistent throughout the manuscript. Source data are provided as a Source Data file.

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