Fig. 2: T cell macropinocytosis.
From: Macropinocytosis drives T cell growth by sustaining the activation of mTORC1
a, b SEM images of murine CD4+ T cells, unstimulated or stimulated with CD3/28 mAb for 16 h. Macropinocytic cups at different stages of development are indicated (arrows). c SEM image of a murine BM macrophage stimulated with CSF1 for 15 min. Note similarity of macropinocytic cups to those identified in T cells (arrows). d Murine CD4+ T cells, stimulated with CD3/28 mAb for 16 h, were fixed and permeabilized, stained with Alexa 488-labeled phalloidin and anti-CD4 mAb, and analyzed by confocal microscopy. Shown images are 3 μm above the plane of T cell contact with the substratum. Note cell surface projected loop of polymerized actin (arrows).
