Fig. 4: Long-term stability of the PDMS-encapsulated crack sensor integrated with silicone rubber cantilever.
a, b Representative traces of real-time change in resistance ratio and displacement of the cardiomyocytes cultured PDMS-encapsulated crack sensor at day 5 and 26 of the culture days. c Displacement of the cardiomyocytes seeded PDMS-encapsulated crack sensor integrated with silicone rubber cantilever at different culture periods. d, e Relative contraction force, and a beat rate of the cardiomyocytes at different culture periods. f Rise time and decay time of cultured cardiomyocytes measured over 26 days. c–e (**p < 0.01 measures by two-way ANOVA followed by Tukey’s honest significant difference test). The rise time and decay time were analyzed, and beat rate corrected with Fridericia’s formula (Rise time corrected (Rc) = R/interspike interval1/3) and (Decay time corrected (Dc) = D/interspike interval1/3), respectively. (*p < 0.05, **p < 0.01 measures by one-way ANOVA followed by Tukey’s honest significant difference test). Error bars are mean ± s.d. (n = 5 biologically independent samples). NS and D represent displacement and nonsignificant, respectively.
