Fig. 7: Change in contractility of the quinidine treated cultured cardiomyocytes.
a Representative real-time traces of change in sensor resistance ratio and cantilever displacement owing to the contraction and relaxation of different concentration of quinidine treated cardiomyocytes. b, c Bar plot depicting the cantilever displacement and relative contraction force generated by cardiomyocytes (**p < 0.01 measures by one-way ANOVA followed by Tukey’s honest significant difference test.). d Beat rate of cardiomyocytes at quinidine concentrations of 1 nM and 10 µM. e Beat rate of quinidine treated cardiomyocytes at different concentrations (1 nM–100 µM). f Change in resistance of the cardiomyocytes seeded cantilever at different quinidine concentrations (1 nM–100 µM). g Rise time and decay time of cardiomyocytes at quinidine concentrations of 1 nM and 10 µM. The rise time and decay time were analyzed and beat rate corrected with Fridericia’s formula (Rise time corrected (Rc) = R/interspike interval1/3) and (Decay time corrected (Dc) = D/interspike interval1/3), respectively. (*p < 0.05, **p < 0.01 measures by one-way ANOVA followed by Tukey’s honest significant difference test.). Error bars are mean ± s.d. (n = 5 biologically independent samples). D is representsdisplacement.
