Table 3 The rates of somatic measure change with age are different between middle-aged and old individuals.

From: The Medical Genome Reference Bank contains whole genome and phenotype data of 2570 healthy elderly

Measure

ASRB

45 and Up Study

ASPREE

Individuals

344

717

1853

 Percent female

ND

59.3%

48.2%

Median age (range)

40 (18–65)

70 (64–1)

79 (75–95)

Telomere length (AU/decade)

−0.115 [−0.157, −0.073]

0.040 [−0.010, 0.090]

0.115 [0.035, 0.196]

Mitochondria count (log10 mt/nucleus/decade)

−0.004 [−0.018, 0.010]

−0.046 [−0.065, −0.027]

−0.038 [−0.059, −0.017]

Y copy number in males (Y chromosomes/nucleus/decade)

−0.011 [−0.022, 0.001]

−0.050 [−0.068, −0.033]

−0.043 [−0.065, −0.021]

Somatic variant burden (log10 variants/Mb/decade)

0.038 [−0.002, 0.079]

0.207 [0.167, 0.247]

0.228 [0.173, 0.282]

Mitochondrial variants (mt variants/decade)

0.051 [−0.177, 0.278]

1.665 [1.315, 2.015]

0.893 [0.195, 1.591]

  1. Numbers show the rate of change of each somatic measure with age in the middle-aged ASRB cohort (median age 40), and the older MGRB cohorts (median age 70 or older). Changes are significantly different between the younger ASRB and older MGRB cohorts, and consistent within the two older MGRB cohorts. Linear model slopes as change per decade are reported for each of five somatic measures in each cohort, with 95% Wald confidence intervals. Values significantly different from zero are represented in bold. Note that somatic burden and mitochondrial count per nucleus are reported on the natural logarithm scale. ND, not determined due to data use agreement constraints
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