Fig. 1: Intravaginal N-9 disrupts cervical epithelial morphology during pregnancy. | Nature Communications

Fig. 1: Intravaginal N-9 disrupts cervical epithelial morphology during pregnancy.

From: Cervical epithelial damage promotes Ureaplasma parvum ascending infection, intrauterine inflammation and preterm birth induction in mice

Fig. 1

In the morning of D17 of gestation, mice received either N-9 (2% n = 4, 5% n = 3 or 10% n = 4 in PBS) or PBS control (n = 4) via intravaginal inoculation. After 8 h, mice were sacrificed for tissue collections. Cervical tissue sections were stained with AB/PAS and a morphological damage scoring system was used to assess epithelial damage (a). N-9 significantly damages the morphology of the cervical epithelium during pregnancy (b). Error bars indicate SD. Statistical significance was assessed using one-way ANOVA with Dunnett’s multiple comparisons test against PBS group (**P < 0.005 for 2% N-9 and 10% N-9 vs. PBS, *P < 0.05 for 5% N-9 vs. PBS). Source data are provided as a Source Data file.

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