Fig. 1: NC Adar1 deletion leads to global depigmentation, tremor, and early lethality in mice.
From: ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development
a Breeding strategy used to generate neural crest-specific Adar1 conditional knockout mice making use of the HtPA-Cre line. YFP allele is indicated in green; mutant genotype in blue. b Genotypes distribution and viability analysis at birth (postnatal day 0, P0). The number of animals of each genotype was compared to the expected ones to analyze viability. c Photos and body weight graphs of wild-types (WT, n = 11 at each stage), heterozygotes (Het, n = 3 at P0 and n = 4 at P4) and homozygous mutants (Mut, n = 7 at each stage) mice at P0 and P4. Note the significant body weight reduction at P4 and the total depigmentation of mutant mice. Asterisks represent p value: ***p < 0.001 determined using one-way ANOVA. d Survival rate (%) of wild-types (black), heterozygotes (gray) and mutants (blue) over time (days). Note that all mutants died within the first 10 days of life.
