Fig. 6: Activation of an injury-associated gene expression program in mutants.

a Venn diagram showing significant overlap between RNA-seq data generated in this study (orange) and differentially expressed genes upon peripheral nerve injury (blue)^39,40. The number of genes in each category, the % of overlap and representative genes are indicated. Fisher’s exact test confirmed enrichment (p < 2.2E-16). Note that 1028 out of 3009 genes we found deregulated are overlapping with published datasets. b Validation of a subset of differentially expressed genes by RT-qPCR. All data represent mean ± SEM. Statistical differences between the groups (n = 4–6 controls and n = 4–8 mutants depending on tested genes) were determined using t test (asterisks represent p values: *p < 0.05, **p < 0.01, ***p < 0.001). Source data are provided as a source data file. c Of the 111 EMT-associated genes found to be differentially expressed between uncut and cut nerves³⁹, 34% were also deregulated upon Adar1 deletion. Top 10 up-(pink) and down-(green) regulated genes found in common, (p-adj < 0.05) are indicated. Note that “EMT-associated genes” are more generally associated to migration and cell adhesion function.