Table 1 Clusters of variations across 78 Y. pestis isolates†.

From: Evolutionary selection of biofilm-mediated extended phenotypes in Yersinia pestis in response to a fluctuating environment

K*

N# (in bp)

CO92 position

Probability of cluster under neutral substitution model

Genes or genome regions involved

8

127

52,546-52,672

P < 0.00001

rpoZ (RNA polymerase ω-subunit)

5

2904

2,326,351-2,329,254

P = 0.00013

CutC (copper homeostasis protein); YPO2050; intergenic; YPO2051

2

2

358,874-358,875

P = 0.0034

aspA (aspartate ammonia-lyase)

2

5

581,519-581,523

P = 0.013

Intergenic; YPO0535–YPO0536

2

15

3,705,090-3,705,104

P = 0.048

YPO3321; YPO3322

  1. †Two small clusters (at CO92 position 2,577,933 and 2,606,316) were excluded as they were the result of copy-number variations in tandem repeat loci
  2. *K, the number of variations within a cluster
  3. #N, region size of the cluster
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