Fig. 5: Orthotopic livertumor targeting of Pt NPs in vivo.
From: Blood-triggered generation of platinum nanoparticle functions as an anti-cancer agent
a Anatomical location (left) and MIR imaging (right) of orthotopic liver tumors in 5 nude mice; b NIR image of tumors 1–3 d after intravenous injection with 1 mg kg−1 ICG-conjugated Pt NPs (1, 2, 3) or 1 mg kg−1 ICG-conjugated chem-Pt NPs (HSA prepared Pt NPs; 4, 5), c Three dimensional reconstruction of the NIR images of the orthotopic liver tumor models treated with 1 mg kg−1 ICG-conjugated Pt NPs (1, 2, 3); d Anatomical location (left) and MIR imaging (right) of the orthotopic liver tumors; e NIR image of a tumor 1–2d after intravenous injection with 1 mg kg−1 ICG-conjugated Pt NPs (1) or 1 mg kg−1 albumin bound Paclitaxol (Abraxane)-ICG (2) treatment. f Three dimensional reconstruction of the NIR image of the tumor after treatment with 1 mg kg−1 ICG-conjugated Pt NPs (1). All red circles indicate the tumor location.
