Table 1 Univariate and multivariate Cox regression analyses for progression-free survival and overall survival in N+ breast cancer patients–119 cases (LN cohort).
Disease-free survival | Overall survival | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Univariate | Multivariate | Univariate | Multivariate | ||||||||||
Hazard ratio | 95% CI | p Value | Hazard ratio | 95% CI | p Value | Hazard ratio | 95% CI | p Value | Hazard ratio | 95% CI | p Value | ||
LN stromal percentage | Low % (reference) | 1 | – | – | 1 | – | – | 1 | – | – | 1 | – | – |
High % | 2.1 | 1–4.3 | 0.05 | 2.6 | 1.2–5.9 | 0.02 | 2.1 | 0.9–4.6 | 0.07 | 2.8 | 1.2–6.6 | 0.02 | |
LN CAF enrichment | CAF-S1 (reference) | 1 | – | – | 1 | – | – | 1 | – | – | 1 | – | – |
CAF-S4 | 1.1 | 0.5–2.3 | 0.9 | 1.4 | 0.6–3.3 | 0.4 | 2.1 | 0.8–5.4 | 0.1 | 3.4 | 1.2–9.8 | 0.02 | |
LN status at diagnosis | N1 (reference) | 1 | – | – | 1 | – | – | 1 | – | – | 1 | – | – |
N2 | 2.1 | 1–4.8 | 0.07 | 2.5 | 1.1–5.8 | 0.03 | 1.9 | 0.8–4.6 | 0.1 | 2.0 | 0.8–4.9 | 0.1 | |
N3 | 5.3 | 2.1–13 | 0.0004 | 4.6 | 1.8–12 | 0.002 | 4.5 | 1.7–11.8 | 0.002 | 3.3 | 1.2–8.9 | 0.02 | |
BC subtype | Lum A (reference) | 1 | – | – | 1 | – | – | 1 | – | – | 1 | – | – |
Lum B | 1.1 | 0.4–3.2 | 0.8 | 0.7 | 0.2–2.0 | 0.5 | 2.6 | 0.7–9.4 | 0.1 | 1.7 | 0.5–6.3 | 0.4 | |
HER2 | 0.7 | 0.2–2.4 | 0.5 | 0.7 | 0.2–2.7 | 0.6 | 1.4 | 0.3–6.2 | 0.7 | 1.8 | 0.4–8.7 | 0.5 | |
TN | 3.0 | 1.1–8.0 | 0.03 | 3.9 | 1.4–11 | 0.009 | 5.3 | 1.5–19 | 0.01 | 7.3 | 2.0–27 | 0.003 | |
