Fig. 4: Piezo1 deficiency resisted to bone loss induced by unloading.
From: Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk
a 3D μ-CT images of trabecular bones of distal femurs isolated from male WT and Prx1Cre, Piezo1fl/fl mice, subjected with tail-suspended for one week trial or ground control, respectively, sacrificed at 7-week-old. b–f μ-CT analysis of distal femurs for bone mineral density (BMD) (b), bone volume per tissue volume (BV/TV) (c), trabecular number (Tb.N) (d), trabecular thickness (Tb.Th) (e) and trabecular spacing (Tb.Sp) (f). Data are mean ± SD, n ≥ 5. g TRAP staining of the femurs isolated from male WT and Prx1Cre, Piezo1fl/fl mice, subjected with tail-suspended trial or ground control, respectively. Scale bar = 50 μm. h Quantification of the TRAP staining by osteoclast surface per bone surface (Oc.S/BS). Data are mean ± SD, n = 3. *P < 0.05; **P < 0.01. Ordinary one-way ANOVA. Source data are provided in the Source Data File.
