Fig. 4: SFB+ microbiota is sufficient for cPTH to expand intestinal and BM Th17 cells. | Nature Communications

Fig. 4: SFB+ microbiota is sufficient for cPTH to expand intestinal and BM Th17 cells.

From: PTH induces bone loss via microbial-dependent expansion of intestinal TNF+ T cells and Th17 cells

Fig. 4

a Relative frequency of PP Th17 cells, n = 9–10 mice per group. b Absolute number of BM Th17 cells, n = 9–10 mice per group. c Small Intestine levels of Il17a transcripts, n = 5 mice per group. d BM levels of Il17a transcripts, n = 5 mice per group. SFB+ TAC and JAX mice and SFB− JAX mice were treated with cPTH with antibiotics (Abx) or without antibiotics (No Abx) for 2 weeks. Data are expressed as Mean ± SEM. All data were normally distributed according to the Shapiro-Wilk normality test. Data were analyzed by two-way ANOVA and post hoc tests applying the Bonferroni correction for multiple comparisons. *p < 0.05, **p < 0.01,***p < 0.001, and ****p < 0.0001 compared to the indicated group. Source data are provided as a Source Data file.

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